SCIENTIFIC PROGRAMME




PLEASE NOTE THAT ACCESS TO THE ABSTRACT BOOK IS RESTRICTED TO REGISTERED PARTICIPANTS OF THE SYMPOSIUM

                         

TUESDAY - 11 JUNE

14:00                Registration

17:30 - 18:30     Welcome cocktail

18:30 - 19:00     Opening (Robert Feulgen Prize + Young Scientists Awards)

19:00 - 19:45     Keynote speech - Robert Feulgen lecturer -
                        Prof. Robert D. Goldman, Feinberg School of Medicine, Northwestern University, Chicago:
                        "Intermediate Filaments: Rare Diseases Provide Insights Into Their Cytoskeletal and Nucleoskeletal Functions"

14:00 - 20:00 - Exhibition
WEDNESDAY - 12 JUNE

9:00 - 11:00       Session 1 Regulation of IF Assembly and Dynamics in Vivo and in Vitro

Session chairs: Mirjana Liovic, Roy Quinlan

Invited speakers:
Harald Herrmann: "Principles of Intermediate Filament Assembly: Keratins to Lamins"
Harish C. Pant: "Topographic Regulation of Neuronal Intermediate Filament Proteins in Health and Disease"

Contributed presentations:
Roy Quinlan: “Desmin, AlphaB-Crystallin and the Legacy of the R120G Mutation
Thomas Dechat: “The Influence of LAP2alpha on the Assembly Properties of A-type Lamins
Stephanie Portet: “Mathematical Modelling of IF Assembly
Marcin Moch: “Computational Analysis of Keratin Network Dynamics in Response to Epidermal Growth Factor Stimulation and Plectin Downregulation

11:00 - 11:30      Coffee break

11:30 - 13:00      Session 2 IF Structure, Mechanical Properties and Mechanotransduction

Session chairs: Marco Biggiogera, Jaroslav Mokrý

Invited speakers:
Ohad Medalia: "Insight into the Functional Organization of Lamins"
Norbert Mücke: "Assembly Kinetics and Mechanical Properties of Cytoplasmic Intermediate Filaments"

Contributed presentations:
Tomas Venit: “Atomic Force Microscopy Reveals Differences in Cell Membrane Properties in Nuclear Myosin I Mutant
Balasz Kiss: “Nanomechanics of Desmin Filaments Explored with Force-Clamp Optical Tweezers

13:00 - 13:45       FEI lunch workshops (Diane Van Rossum):

- New Dimensions in 3D Volume Imaging Using Electron Microscopy Techniques
- New Tools for Correlative Light and Electron Microscopy

13:45 - 15:15        Session 3 IF Associated Proteins and Regulatory Crosstalk in a Cell

Session chairs: Roland Foisner, Klara Weipoltshammer

Invited speaker:
Gerhard Wiche: "Distinct Roles of Plectin Isoforms in Skeletal Muscle"

Contributed presentation:
Giovanna Lattanzi:  "SUN1 as a Key Player in the Onset of Muscular Dystrophy"

Invited speaker:
Yassemi Capetanaki: "Μyospryn: a Multifunctional Desmin-Associated Protein

Contributed presentation:
Tina Zupancic: “The Effects of Ionizing Radiation on Keratin 5 or 14 Mutant Keratinocytes

15:15 - 16:00         Poster Session / Coffee break

16:00 - 18:00         Session 4 IFs in Pathology and Diagnostics

Session chairs: Pavel Strnad, Axel Walch

Invited speakers:
Nam-On Ku: "Caspase Cleavage-Resistant Keratin 18 Mutation Protects Liver from Apoptosis in Transgenic Mice" - Histochemistry and Cell Biology Lecture
Diana Toivola: "Keratins as Disease Modulators in the Intestine and Endocrine Pancreas"

Contributed presentations:
Cheng Fang: “Vimentin Regulates Epithelial-to-Mesenchymal Transition and Fibroblast Proliferation Involved in the Healing of Cutaneous Wounds
Serena Bonin: “Luminal and Basal Cytokeratins in Breast Cancer Lymph Node Positive Patients as Markers of Disease Progression
Mirjana Liovic: “The K18 S230T Mutation Displaces Tight Junction Proteins Claudin 4 and ZO-1 and Results in Increased Paracellular Permeability in Vitro
Joel Nyström: “Keratin Intermediate Filaments as Regulators of Colon Energy Metabolism

9:00 - 18:00           Exhibition

THURSDAY - 13 JUNE

9:00 - 11:00           Session 5 Nuclear Lamins, Chromatin, Nuclear Architecture and Laminopathies

Session chairs: Gisele Bonne, Vlada Filimonenko

Invited speakers:
Roland Foisner: "Nucleoplasmic Lamins Regulate Chromatin Organization and Gene Expression in Tissue Progenitor Cells"
Yosef Gruenbaum: "Regulation of Aging and Metabolism by the C. Elegans Nuclear Lamina"

Contributed presentations:
Vlada Filimonenko: “Lamins and Phospholipids - New Complexes in the Cell Nucleus?
Ryszard Rzepecki: “Drosophila Lamins and Topo II Participate in Genome-Wide Chromatin Reorganization Associated with Transcription Shutdown Induced by Heat Shock
Petros Batsios: “NE81, a Lamin-Like Protein in Lower Eukaryotes
Elisabetta Mattioli: “The LINC Complex Regulates the Microtubule Network Nucleation in Human Muscle

11:00 - 11:30          Coffee break

11:30 - 13:00          Session 6 IFs of the Nervous System: Function in CNS Pathologies

Session chairs: Miroslava Anděrová, Paul Debbage

Invited speakers:
Joel Eyer: "Neurofilaments: Unexpected Clinical Findings from Basic Research"
Miloš Pěkný: "Astrocyte Intermediate Filaments in CNS Diseases and Regeneration"

Contributed presentations:
Claire Lepinioux-Chambaud: “The Neurofilament Light Tubulin Binding Site Peptide (NFL-TBS.40-63) Enters Selectively in Glioma Cells by Endocytosis
Caterina Giacomini: “Alterations of Lamin B1 Levels Affect Viability and Morphology in Primary Murine Neuronal Cultures

13:00 - 13:45          Lunch

13:45 - 15:15          Session 7 Advances in Imaging Techniques for Cell Biology Studies

Session chairs: Pavel Hozák, Jürgen Roth

Contributed presentations:
Michaela Aichler: “MRI-Compatible Pipeline for Three-Dimensional MALDI Imaging Mass Spectrometry Using PAXgene Fixation
Alexander V. Dulebo: “Atomic Force Microscopy in Intermediate Filaments Research

Commercial presentations:
Przemyslaw Fleszar (Application Specialist, GE Healthcare): "New Dimension in High Content Analysis and Super Resolution"

LEICA presentations:

Zdeněk Rous: "New Confocal Platform for Superresolution, Supersensitivity, Superspeed"

Andreas Nowak: "News in Leica TEM and SEM Specimen Preparation"

15:15 - 16:00          Poster Session / Coffee break

16:00 - 16:45          EMBO lecture - Ueli Aebi: "IF Research - Quo Vadis?"

17:00 - 18:00          Society for Histochemistry Business Meeting

19:00 - 22:00          Banquet at the Letenský chateau

  9:00 - 17:00 - Exhibition

FRIDAY - 14 JUNE

9:30 - 10:05             R. Feulgen Prize laureate lecture Prof. Yaron Shav-Tal, Mina & Everard Goodman Faculty of Life
                              Sciences, Bar Ilan University
: “Dynamics of Gene Expression in Real-Time Measured on Single Genes in
                              Single Living Cells“

10:05 - 11:05           Session 8 Free Topics

Session chairs: Fang Cheng, Ansgar Brüning

Contributed presentations:
Sukriye Yildirim: “Involvement of Phosphatidylinositol 4,5-Bisphosphate in RNA Polymerase I Transcription
Muhammad Nadeem Asghar: “Dramatic Loss of the Chloride Transporter DRA in Mouse Intestinal Epithelia after Keratin 8 Inactivation
Michaela Aichler: “Clinical Response to Chemotherapy in Oesophageal Adenocarcinoma Patients is Linked to Defects in Mitochondria
Hyun-Woo Rhee: “APEX, a Genetically Encoded Tag for Spatial Proteome Mapping & EM Imaging

11:05 - 11:30           Closing + poster award

11:30 - 12:00           Coffee break

9:30 - 12:00 - Exhibition




PLEASE NOTE THAT ACCESS TO THE ABSTRACT BOOK IS RESTRICTED TO REGISTERED PARTICIPANTS OF THE SYMPOSIUM





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